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91.
Experiments were carried out to elucidate the role of central catecholamines in regulating catecholamine metabolism in the vas deferens and adrenal gland of the rat. Rats were injected intracerebroventricularly (i.c.v.) with either vehicle or 6-hydroxydopamine (6-OHDA). Groups of animals pretreated with vehicle or 6-OHDA (i.c.v.) were injected intraperitoneally (i.p.) with alpha-methyl-para-tyrosine (AMT), a tyrosine hydroxylase inhibitor. Catecholamine turnover rates were estimated by determining norepinephrine or epinephrine content after administrating AMT.Central norepinephrine and dopamine contents decreased significantly (p<0.05) after treatment with 6-OHDA and AMT. The norepinephrine content of the vas deferens of rats pretreated with 6-OHDA was markedly reduced (p<0.001) after administration of AMT, whereas that of the vehicle-treated rats remained unchanged. Administration of 6-OHDA had no effect on the norepinephrine or epinephrine content of the adrenal gland.The present results indicate that central monoaminergic neurons have an inhibitory effect on the adrenergic neurons of the vas deferens. In contrast, this inhibitory regulation does not appear to be exerted on the adrenal glands. 相似文献
92.
A diffusion chamber technique based on time-lag analysis for the estimation of effective diffusion coefficients of radiolabelled macromolecules of varying molecular weights through native mucus gel is reported. For all solutes studied, a reduction in effective diffusion coefficients was observed with a retardation of solute flux in both aqueous and mucus layers. Over the molecular weight range of solutes investigated (126-186,000 Daltons), a consistent effect of molecular weight was evident with regard to the retarding effect of mucus. No apparent or absolute molecular weight cut-off for macromolecular transfer was exhibited. However, at high molecular weights (greater than 30,000 Daltons) the retardation was greatly enhanced. The results confirm that mucus can be regarded as a gel with finite pores, but that it does not constitute an absolute barrier to even high molecular weight solutes. 相似文献
93.
94.
Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor 总被引:2,自引:0,他引:2
Takahashi C Contreras B Iwanaga T Takegami Y Bakker A Bronson RT Noda M Loda M Hunt JL Ewen ME 《Nature genetics》2006,38(1):118-123
Mutations in the gene encoding the retinoblastoma tumor suppressor predispose humans and mice to tumor development. Here we have assessed the effect of Nras loss on tumor development in Rb1 heterozygous mice. Loss of one or two Nras alleles is shown to significantly reduce the severity of pituitary tumors arising in Rb1(+/-) animals by enhancing their differentiation. By contrast, C-cell thyroid adenomas occurring in Rb1(+/-) mice progress to metastatic medullary carcinomas after loss of Nras. In Rb1(+/-)Nras(+/-) animals, distant medullary thyroid carcinoma metastases are associated with loss of the remaining wild-type Nras allele. Loss of Nras in Rb1-deficient C cells results in elevated Ras homolog family A (RhoA) activity, and this is causally linked to the invasiveness and metastatic behavior of these cells. These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression. 相似文献
95.
李惠玲 《玉林师范学院学报》2004,25(2):115-118
从高校非中文专业学生知识结构的现状出发,阐述加强人文素质教育的重要性;“中国古典文学鉴赏”课的课程特点及其在人文素质教育中所起的作用决定了在高校非中文专业学生中开设这门课程的必要性和可行性。 相似文献
96.
We investigated the sound communication associated with mating inNezara viridula (L.) to clarify conflicting reports on the medium through which acoustic signals are borne. Recordings made from virgin pairs ofN. viridula during precopulatory and compulatory behaviour have revealed that signals transmitted as vibrations through the substrate are a more likely means of communication than signals transmitted by a radiation of sound pressure waves through the air (at least in Australian populations). We present evidence (additional to that already in the literature) that air-borne acoustics are an unlikely mechanism of sexual communication in this species. Specifically, the recorded pulse train patterns showed no consistency or repeatability in relation to different stages of mating behaviour. In contrast, frequency spectrograms of substrate-borne signals reveal repeatable patterns that do correspond with the stage of mating behaviour. 相似文献
97.
提出了一个关于氧化物半导瓷晶界势垒起源的新观点,认为晶界势垒起源于烧结过程中外界氧在晶界中的扩散,与材料的结构、化学缺陷、掺杂、外界气氛、烧结工艺、组成状态等有密切关系,并用此理论解释了许多实验现象。 相似文献
98.
论述了交织编码的工作原理,给出了一种交织扩展Golay码的改进型软件设计方案,用TMS320C25实现了其编译码器并给出了模拟实验结果。实验结果表明,它能准确地纠正不大于72比特位的差错;处理128×128×8比特位的一幅图像数据的运行时间为0.412s. 相似文献
99.
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition 总被引:2,自引:0,他引:2
K. Brune W. S. Beck G. Geisslinger S. Menzel-Soglowek B. M. Peskar B. A. Peskar 《Cellular and molecular life sciences : CMLS》1991,47(3):257-261
Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics. 相似文献
100.